Continuous Manufacturing Pharma & CDMO Services by Bridge Health

Current Project: Empowering the Future of Malaria Treatment: The Flow Chemistry Project by BridgeBSS

Project Overview

The Flow Chemistry Project is a pioneering U.S. Government-led initiative aimed at revolutionizing the production of critical pharmaceutical ingredients. This ambitious project is managed by BridgeBSS Health as the prime contractor and Project Management Office (PMO). The project collaborates closely with Manus, which brings its cutting-edge biomanufacturing expertise, and ArtemiFlow USA, the technology owner responsible for the R&D behind the patented continuous-flow synthesis process.

Why It Matters

The production of essential pharmaceuticals has traditionally faced inefficiencies and challenges. The Flow Chemistry Project addresses these by utilizing a high-efficiency continuous-flow synthesis technology that guarantees a robust, high-purity supply of critical APIs.

We Pioneer a Model for Cost-Effective, Scalable Drug Manufacturing

By leveraging continuous chemistry, we are laying the groundwork for future advancements that will drive efficiency and sustainability in the pharmaceutical industry. This innovative approach is a model for the future, enabling more efficient, scalable, and environmentally responsible drug production.

Key Features of the Project

• U.S. Government Leadership: The project is led with full support from the U.S. Government, emphasizing the critical need for secure domestic production capabilities for vital pharmaceutical ingredients.
• Innovative Technology: The project utilizes a patented High Power LED Source integrated into a Photooxidation Reactor; a specialized piece of equipment that powers the continuous-flow synthesis process in the upstream production stage.
• Upstream & Downstream Processes: Our continuous-flow manufacturing process ensures precise control over the reaction conditions, providing higher yields and purity. For downstream processing, a batch processing method is applied, ensuring efficient product isolation, purification, and crystallization.
• Sustainability: Designed with energy-efficient systems like LED UV light sources and solvent recovery processes, this project minimizes its environmental footprint while optimizing the synthesis process.
• Regulatory Compliance: The project adheres to FDA cGMP standards and 21 CFR Part 11 guidelines, ensuring full traceability, data security, and the highest quality control standards for pharmaceutical production.
• Timeline & Milestones: The project is progressing with key milestones, including Design Freeze in December 2025, Equipment Installation by June 2026, and commissioning to be completed by December 2026.
• Risk Management: Comprehensive risk mitigation strategies are in place to manage potential challenges such as vendor delays, supply chain disruptions, and regulatory changes.

Collaborative Synergy

This collaboration unites the expertise of Bridge Health, ArtemiFlow USA, Manus, and U.S. Government support. It combines world-class continuous flow chemistry technology with established biomanufacturing capabilities, ensuring an efficient, safe, and high-quality path to market for essential pharmaceutical products.

Join Us in Strengthening Global Health

With the backing of the U.S. Government, this project not only accelerates domestic production but also strengthens global health security by ensuring the continuous availability of vital medications for malaria treatment and other diseases.

Call for Partners

We invite suppliers and vendors to contribute by providing specialized equipment, including cGMP-capable flow reactors, High Power LED sources, specialized chilling/heating units, advanced crystallizers, and Process Analytical Technology (PAT) solutions. Together, we can create a lasting impact on global health and the future of pharmaceutical production.

For partnership opportunities or to submit your bid, please feel free to check on our Tenders.

Bridge Health - Pioneering Solutions for a Healthier Tomorrow.